Nature Neuroscience, Published online: 05 September 2025; doi:10.1038/s41593-025-02059-1Lithium limiting AD pathology

Nature Neuroscience, Published online: 05 September 2025; doi:10.1038/s41593-025-02058-2Vagus block blocks cachexia

Nature Neuroscience, Published online: 26 August 2025; doi:10.1038/s41593-025-02045-7When navigating through the world, we can predict our next location on the basis of an internal sense of our location and velocity, but we can also orient to external visual sensory cues to update and stabilize this sense of location and velocity. A new experiment that mismatches the speed of visual cues and physical movement in rats shows that hippocampal network dynamics rapidly alternate between these functions within cycles of the 8-Hz theta oscillation. In one portion of the theta cycle, the internal sense of location drives the phase of firing independent of visual cues or self-motion cues, whereas in the other portion, the phases depend on a match of visual and self-motion inputs, manifesting as a reduction in place cell activity when there is a mismatch.

Nature Reviews Neurology, Published online: 11 August 2025; doi:10.1038/s41582-025-01130-6Robert Joyce has lived with multiple sclerosis for over 30 years. Here, he highlights the problems with using standard test scores to assess changes in physical and cognitive function and calls for testing to ensure that individual baselines are recorded.