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Medizin

Aktuelle Forschungsergebnisse aus verschiedenen Gebieten der Humanmedizin

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Kardiologie

ANGPTL3-lowering strategies to address residual cardiovascular risk

Farzahna Mohamed

Nature Reviews Cardiology, Published online: 10 March 2026; doi:10.1038/s41569-026-01273-zANGPTL3-lowering strategies to address residual cardiovascular risk

Antiphospholipid antibodies and cardiovascular thrombosis

Nature Reviews Cardiology, Published online: 10 March 2026; doi:10.1038/s41569-026-01269-9Antiphospholipid antibodies (aPL) are associated with an elevated risk of thromboembolic events in patients with antiphospholipid syndrome and, increasingly, in those without previous thrombosis. In this Review, Bikdeli and colleagues discuss the clinical relevance of aPL seropositivity in predicting the risk of thrombotic cardiovascular events, summarize potential management strategies and identify key knowledge gaps that warrant further research.

The City Heartbeat Index as a benchmarking tool for urban cardiovascular health

Nature Reviews Cardiology, Published online: 03 March 2026; doi:10.1038/s41569-026-01267-xCities are dense population hubs where lifestyle, environmental and socioeconomic factors influence health outcomes, including morbidity and mortality secondary to cardiovascular disease. The City Heartbeat Index offers a city-level benchmarking framework that enables policy leaders to assess and implement the prevention and management of cardiovascular disease in urban environments.

Author Correction: The effects of skeletal muscle and adipose tissue on outcomes in patients with heart failure

Wolfram Doehner

Nature Reviews Cardiology, Published online: 02 March 2026; doi:10.1038/s41569-026-01272-0Author Correction: The effects of skeletal muscle and adipose tissue on outcomes in patients with heart failure

Understanding atrial failure: from diagnosis to clinical implications

Bryce Alexander

Nature Reviews Cardiology, Published online: 27 February 2026; doi:10.1038/s41569-026-01266-yAtrial failure is an emerging clinical syndrome that results from an underlying atrial cardiomyopathy and manifests with clinical symptoms. In this Review, Baranchuk and colleagues detail the pathophysiological mechanisms, clinical phenotypes and multimodality imaging of atrial failure as well as emerging therapeutic strategies to reverse atrial remodelling.

The effects of skeletal muscle and adipose tissue on outcomes in patients with heart failure

Wolfram Doehner

Nature Reviews Cardiology, Published online: 24 February 2026; doi:10.1038/s41569-026-01268-wThe effects of skeletal muscle and adipose tissue on outcomes in patients with heart failure

Reply to: ‘The effects of skeletal muscle and adipose tissue on outcomes in patients with heart failure’

Nature Reviews Cardiology, Published online: 24 February 2026; doi:10.1038/s41569-026-01270-2Reply to: ‘The effects of skeletal muscle and adipose tissue on outcomes in patients with heart failure’

HFpEF and MASLD: converging mechanisms and clinical implications

Federico Capone

Nature Reviews Cardiology, Published online: 23 February 2026; doi:10.1038/s41569-026-01257-zSchiattarella and colleagues propose a framework linking heart failure with preserved ejection fraction and metabolic dysfunction-associated steatotic liver disease as interconnected syndromes rather than coincidental comorbidities. The authors delineate shared metabolic, inflammatory and endocrine drivers and propose a shift towards coordinated strategies and integrated clinical algorithms to improve prevention, risk stratification, early detection and co-management of these disorders.

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Klinische Onkologie

Author Correction: Innovative approaches for lung cancer screening and interception

Nature Reviews Clinical Oncology, Published online: 10 March 2026; doi:10.1038/s41571-026-01140-3Author Correction: Innovative approaches for lung cancer screening and interception

Advances in the management of metastatic gastric cancer: current strategies and emerging therapeutics

Nature Reviews Clinical Oncology, Published online: 10 March 2026; doi:10.1038/s41571-026-01134-1The development of immune checkpoint inhibitors and novel targeted therapies and the incorporation of these agents into first-line therapy for biomarker-selected patients with metastatic gastric cancer has improved outcomes. Nonetheless, many challenges remain, including both primary and acquired resistance as well as a lack of relevant biomarkers in certain subgroups. In this Review, the authors describe the current approach to first-line therapy for patients with metastatic gastric cancer as well as emerging approaches that might improve the standard of care in the coming years.

Glucagon-like peptide 1 receptor agonists and cancer risk: the good, the bad and the unknown

Edoardo Mannucci

Nature Reviews Clinical Oncology, Published online: 09 March 2026; doi:10.1038/s41571-026-01135-0Glucagon-like peptide 1 receptor agonists (GLP1RAs) are widely used by individuals with type 2 diabetes mellitus (T2DM) and/or obesity. Both of these conditions are also associated with an increased risk of certain cancers, and this risk might be ameliorated following intentional weight loss, which can consistently be achieved with GLP1RAs. Conversely, several reports have suggested an increased risk of certain cancers, such as medullary or non-medullary thyroid cancer and pancreatic cancer among those receiving GLP1RAs. In this Review, the authors evaluate these competing risks and the underlying evidence as well as highlighting areas in which evidence is limited and more research will be needed in order to definitively understand the implications of GLP1RAs for cancer risk.

The changing landscape of oncology clinical trials in Latin America

Andreia Cristina de Melo

Nature Reviews Clinical Oncology, Published online: 04 March 2026; doi:10.1038/s41571-026-01137-yAlthough oncology advances stem from clinical research, <5% of global cancer trials actively recruit patients in Latin America. Herein, I discuss why expanding inclusive trial designs and fostering multisector partnerships are essential to reduce disparities and improve the role of Latin America in global oncology research. I present examples such as the recent regulatory reforms in Brazil that aim to accelerate study approvals, as well as collaborative initiatives between local and international research groups to further strengthen clinical trial capacity.

Lisocabtagene maraleucel has high efficacy in R/R MZL

Nature Reviews Clinical Oncology, Published online: 03 March 2026; doi:10.1038/s41571-026-01138-xLisocabtagene maraleucel has high efficacy in R/R MZL

Perioperative approaches for patients with biliary tract cancer

Anudari Zorigtbaatar

Nature Reviews Clinical Oncology, Published online: 03 March 2026; doi:10.1038/s41571-026-01130-5Cholangiocarcinomas, comprising intrahepatic, extrahepatic and perihilar subtypes as well as gallbladder cancer, are a heterogeneous group of malignancies that necessitates a personalized approach to both surgery and systemic therapy. In this Review, the authors describe progress in the development of personalized perioperative therapy strategies as well as the most promising future research directions in this diverse and often difficult-to-treat group of cancers.

Enfortumab vedotin plus pembrolizumab effective in patients with resectable bladder cancer

Nature Reviews Clinical Oncology, Published online: 02 March 2026; doi:10.1038/s41571-026-01139-wEnfortumab vedotin plus pembrolizumab effective in patients with resectable bladder cancer

Translating ferroptosis into oncology: challenges, opportunities and future directions

Nature Reviews Clinical Oncology, Published online: 24 February 2026; doi:10.1038/s41571-026-01128-zDespite substantial interest in exploiting ferroptosis — an iron-mediated, lipid peroxidation-driven form of cell death — for cancer therapy, progress towards clinical translation has been limited. This comprehensive Review describes the major barriers that have restricted ferroptosis-based therapeutic development as well as emerging opportunities presented by new ferroptosis-inducing agents, biomarker-guided patient selection and rational combination treatments.

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Endokrinologie

Peritumoural adipose tissue protects colorectal cancer from immune attack

Nature Reviews Endocrinology, Published online: 11 March 2026; doi:10.1038/s41574-026-01244-xPeritumoural adipose tissue protects colorectal cancer from immune attack

Living with type 1 diabetes mellitus with Black heritage: my personal journey

Nature Reviews Endocrinology, Published online: 09 March 2026; doi:10.1038/s41574-026-01242-zFor nearly three decades, my life has consisted of insulin injections, monitoring of glucose levels and emotional, mental and physical labour. Here, I share my experience of being a Black person living with type 1 diabetes mellitus, including cultural and systemic challenges that affected my access to the care I was entitled to.

Hyperinsulinaemia as a cause of obesity and cardiometabolic diseases

Nature Reviews Endocrinology, Published online: 09 March 2026; doi:10.1038/s41574-026-01240-1This Review outlines the potential role of hyperinsulinaemia as an independent driver of obesity and obesity-related conditions. Evidence regarding the potential causes of hyperinsulinaemia are summarized, and key research gaps are highlighted.

The gut microbiome and ageing trajectories: mechanisms and clinical implications

Andrea Ticinesi

Nature Reviews Endocrinology, Published online: 03 March 2026; doi:10.1038/s41574-026-01236-xThe gut microbiome varies highly between individuals and has a substantial contribution to long-term health. This Review examines the effect of the gut microbiome on ageing and frailty risk, including potential therapies to modify gut microbiome composition to promote healthy ageing.

Dual benefits of HIF activation

Claire Greenhill

Nature Reviews Endocrinology, Published online: 27 February 2026; doi:10.1038/s41574-026-01241-0Dual benefits of HIF activation

The genetics behind thyroid disease

Nature Reviews Endocrinology, Published online: 25 February 2026; doi:10.1038/s41574-026-01238-9The genetics behind thyroid disease

The long-overlooked effect of hypothyroidism on the global burden of non-communicable diseases

Leonidas H. Duntas

Nature Reviews Endocrinology, Published online: 16 February 2026; doi:10.1038/s41574-026-01235-yThis Comment highlights the multiple effects of hypothyroidism and its strong connection to non-communicable diseases (NCDs), serving as a call to action for a global alliance to recognize hypothyroidism as a modifiable risk factor for NCDs. Additionally, it emphasizes the urgent need to raise awareness and improve thyroid management to address the growing burden of NCDs.

Making a droplet: the adipogenin–seipin complex at work

Nature Reviews Endocrinology, Published online: 10 February 2026; doi:10.1038/s41574-026-01234-zAdipogenin is a microprotein expressed in adipose tissue. Previous studies have suggested its role in lipid storage, yet the underlying molecular mechanisms have been unclear. A recent study published in Science presents evidence that adipogenin forms complexes with seipin, a protein that is essential for lipid droplet formation in adipocytes, thereby modulating lipid storage.

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Peritumoural adipose tissue protects colorectal cancer from immune attack

Nature Reviews Endocrinology, Published online: 11 March 2026; doi:10.1038/s41574-026-01244-xPeritumoural adipose tissue protects colorectal cancer from immune attack

Living with type 1 diabetes mellitus with Black heritage: my personal journey

Nature Reviews Endocrinology, Published online: 09 March 2026; doi:10.1038/s41574-026-01242-zFor nearly three decades, my life has consisted of insulin injections, monitoring of glucose levels and emotional, mental and physical labour. Here, I share my experience of being a Black person living with type 1 diabetes mellitus, including cultural and systemic challenges that affected my access to the care I was entitled to.

Hyperinsulinaemia as a cause of obesity and cardiometabolic diseases

Nature Reviews Endocrinology, Published online: 09 March 2026; doi:10.1038/s41574-026-01240-1This Review outlines the potential role of hyperinsulinaemia as an independent driver of obesity and obesity-related conditions. Evidence regarding the potential causes of hyperinsulinaemia are summarized, and key research gaps are highlighted.

The gut microbiome and ageing trajectories: mechanisms and clinical implications

Andrea Ticinesi

Nature Reviews Endocrinology, Published online: 03 March 2026; doi:10.1038/s41574-026-01236-xThe gut microbiome varies highly between individuals and has a substantial contribution to long-term health. This Review examines the effect of the gut microbiome on ageing and frailty risk, including potential therapies to modify gut microbiome composition to promote healthy ageing.

Dual benefits of HIF activation

Claire Greenhill

Nature Reviews Endocrinology, Published online: 27 February 2026; doi:10.1038/s41574-026-01241-0Dual benefits of HIF activation

The genetics behind thyroid disease

Nature Reviews Endocrinology, Published online: 25 February 2026; doi:10.1038/s41574-026-01238-9The genetics behind thyroid disease

The long-overlooked effect of hypothyroidism on the global burden of non-communicable diseases

Leonidas H. Duntas

Nature Reviews Endocrinology, Published online: 16 February 2026; doi:10.1038/s41574-026-01235-yThis Comment highlights the multiple effects of hypothyroidism and its strong connection to non-communicable diseases (NCDs), serving as a call to action for a global alliance to recognize hypothyroidism as a modifiable risk factor for NCDs. Additionally, it emphasizes the urgent need to raise awareness and improve thyroid management to address the growing burden of NCDs.

Making a droplet: the adipogenin–seipin complex at work

Nature Reviews Endocrinology, Published online: 10 February 2026; doi:10.1038/s41574-026-01234-zAdipogenin is a microprotein expressed in adipose tissue. Previous studies have suggested its role in lipid storage, yet the underlying molecular mechanisms have been unclear. A recent study published in Science presents evidence that adipogenin forms complexes with seipin, a protein that is essential for lipid droplet formation in adipocytes, thereby modulating lipid storage.

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GI und Hepatologie

Research without borders: advancing equitable global partnerships to accelerate HBV elimination efforts

Enkhtuul Batbold

Nature Reviews Gastroenterology & Hepatology, Published online: 11 March 2026; doi:10.1038/s41575-026-01186-9The elimination of hepatitis B will not be achieved through innovation alone. It requires dismantling the structural inequities that have long constrained who leads, funds and benefits from global hepatitis B research.

Physical activity and the gut

Nature Reviews Gastroenterology & Hepatology, Published online: 09 March 2026; doi:10.1038/s41575-026-01192-xPhysical activity and the gut

Nature Reviews Gastroenterology & Hepatology, Published online: 06 March 2026; doi:10.1038/s41575-026-01194-9ECCO’26

Long-term data for ileocaecal resection for ileal Crohn’s disease

Nature Reviews Gastroenterology & Hepatology, Published online: 06 March 2026; doi:10.1038/s41575-026-01193-wLong-term data for ileocaecal resection for ileal Crohn’s disease

HIV-associated gut microbiome influences gut mucosal immunity

Nature Reviews Gastroenterology & Hepatology, Published online: 06 March 2026; doi:10.1038/s41575-026-01191-yHIV-associated gut microbiome influences gut mucosal immunity

Microplastics and nanoplastics in the human gut: from signals to standards

Nature Reviews Gastroenterology & Hepatology, Published online: 04 March 2026; doi:10.1038/s41575-026-01185-wThe gastrointestinal tract is a critical interface for microplastic and nanoplastic exposure, yet causal links to health outcomes remain uncertain. We outline current methodological challenges and provide a list of minimum standards for rigorous study design, standardized reporting and careful attention to interpretations to distinguish mechanism from signals.

Metabotherapy for intestinal disease: using metabolites to prevent and treat disorders of the gut

Nature Reviews Gastroenterology & Hepatology, Published online: 02 March 2026; doi:10.1038/s41575-026-01178-9Metabolites are important mediators of metabolism at the cellular and organismal levels. This Review explores the concept of metabotherapy, harnessing metabolites to prevent and treat gastrointestinal disorders, providing insights into metabolite classifications and their pathophysiological mechanisms in health and disease and mapping their potential as therapeutic targets.

Hepatitis C elimination: is it time to redefine the goals?

Nature Reviews Gastroenterology & Hepatology, Published online: 23 February 2026; doi:10.1038/s41575-026-01184-xDirect-acting antiviral agents have substantially improved the rate of sustained virologic response and safety in the treatment of hepatitis C. However, concerns about the long-term outcomes for individuals who achieve sustained virologic response still exist. Herein, we propose a new conceptual model for redefining the goals and strategies of ongoing hepatitis C elimination campaigns.

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Research without borders: advancing equitable global partnerships to accelerate HBV elimination efforts

Enkhtuul Batbold

Nature Reviews Gastroenterology & Hepatology, Published online: 11 March 2026; doi:10.1038/s41575-026-01186-9The elimination of hepatitis B will not be achieved through innovation alone. It requires dismantling the structural inequities that have long constrained who leads, funds and benefits from global hepatitis B research.

Physical activity and the gut

Nature Reviews Gastroenterology & Hepatology, Published online: 09 March 2026; doi:10.1038/s41575-026-01192-xPhysical activity and the gut

Nature Reviews Gastroenterology & Hepatology, Published online: 06 March 2026; doi:10.1038/s41575-026-01194-9ECCO’26

Long-term data for ileocaecal resection for ileal Crohn’s disease

Nature Reviews Gastroenterology & Hepatology, Published online: 06 March 2026; doi:10.1038/s41575-026-01193-wLong-term data for ileocaecal resection for ileal Crohn’s disease

HIV-associated gut microbiome influences gut mucosal immunity

Nature Reviews Gastroenterology & Hepatology, Published online: 06 March 2026; doi:10.1038/s41575-026-01191-yHIV-associated gut microbiome influences gut mucosal immunity

Microplastics and nanoplastics in the human gut: from signals to standards

Nature Reviews Gastroenterology & Hepatology, Published online: 04 March 2026; doi:10.1038/s41575-026-01185-wThe gastrointestinal tract is a critical interface for microplastic and nanoplastic exposure, yet causal links to health outcomes remain uncertain. We outline current methodological challenges and provide a list of minimum standards for rigorous study design, standardized reporting and careful attention to interpretations to distinguish mechanism from signals.

Metabotherapy for intestinal disease: using metabolites to prevent and treat disorders of the gut

Nature Reviews Gastroenterology & Hepatology, Published online: 02 March 2026; doi:10.1038/s41575-026-01178-9Metabolites are important mediators of metabolism at the cellular and organismal levels. This Review explores the concept of metabotherapy, harnessing metabolites to prevent and treat gastrointestinal disorders, providing insights into metabolite classifications and their pathophysiological mechanisms in health and disease and mapping their potential as therapeutic targets.

Hepatitis C elimination: is it time to redefine the goals?

Nature Reviews Gastroenterology & Hepatology, Published online: 23 February 2026; doi:10.1038/s41575-026-01184-xDirect-acting antiviral agents have substantially improved the rate of sustained virologic response and safety in the treatment of hepatitis C. However, concerns about the long-term outcomes for individuals who achieve sustained virologic response still exist. Herein, we propose a new conceptual model for redefining the goals and strategies of ongoing hepatitis C elimination campaigns.

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Nephrologie

‘Missing’ disease-causing variants in Alport syndrome

Nature Reviews Nephrology, Published online: 11 March 2026; doi:10.1038/s41581-026-01061-5Here, the authors discuss explanations for missing disease-causing variants in Alport syndrome, how clinicians and laboratories might manage missing variants and how to care for patients when a clinical suspicion of Alport syndrome exists but no disease-causing variant has been identified.

Bridging structure and function: artificial intelligence-based modelling of kidney proteins

Nature Reviews Nephrology, Published online: 04 March 2026; doi:10.1038/s41581-026-01060-6Advances in artificial intelligence-driven algorithms and experimental technologies have revolutionized the field of protein modelling. This Review describes how these developments have provided unprecedented insights into the structure of key proteins within the kidney, improved understanding of the relationships between protein structure and stability, and enabled mechanistic interpretation of variants that underlie a variety of kidney pathologies.

The impact of social determinants of health on acute kidney injury

Nature Reviews Nephrology, Published online: 04 March 2026; doi:10.1038/s41581-026-01063-3Social determinants of health can have a considerable impact on patient outcomes. Here, the authors examine how social determinants of health contribute to the growing global burden of acute kidney injury and its inequities, and discuss key strategies for tackling disparities in acute kidney injury care and outcomes.

Replenishing methionine protects the host via kidney removal of excess cytokines from blood

Nature Reviews Nephrology, Published online: 02 March 2026; doi:10.1038/s41581-026-01064-2Replenishing methionine protects the host via kidney removal of excess cytokines from blood

Hepatokine regulation of kidney fibrosis

Susan J. Allison

Nature Reviews Nephrology, Published online: 02 March 2026; doi:10.1038/s41581-026-01065-1Hepatokine regulation of kidney fibrosis

When access outpaces ethics: reflections on dialysis expansion and health system integrity

Yot Teerawattananon

Nature Reviews Nephrology, Published online: 17 February 2026; doi:10.1038/s41581-026-01062-4Thailand’s dialysis policy reform, introduced in 2022, aimed to enable universal access to life-sustaining dialysis, but instead exposed systemic vulnerabilities that undermined dialysis quality, compromised patient safety and threatened sustainability of care. These outcomes highlight three ethical dilemmas — access versus quality, continuity of care, and financial conflicts of interest — and offer powerful insights into the ethical tensions that are shaping kidney care globally.

Graph neural networks for computational nephrology

Michael T. Schaub

Nature Reviews Nephrology, Published online: 16 February 2026; doi:10.1038/s41581-026-01059-zGraph neural networks offer a unifying artificial intelligence framework to model related objects, ranging from tissue architecture and geometrical relationships to patient similarity and multi-organ networks. Applications of this technology in nephrology include computational representation of kidney histopathology and modelling of the complex interactions between organs in kidney diseases.

Optimal patient care in advanced chronic kidney disease progressing to kidney failure

Christian Combe

Nature Reviews Nephrology, Published online: 10 February 2026; doi:10.1038/s41581-026-01056-2This Review discusses key strategies for managing patients with advanced chronic kidney disease progressing towards kidney failure. The authors examine drug and lifestyle interventions that can mitigate kidney and cardiovascular risks, and options for addressing kidney failure, including transplantation, dialysis and conservative kidney care, with an emphasis on informed shared decision-making.

Weitere Beiträge

‘Missing’ disease-causing variants in Alport syndrome

Nature Reviews Nephrology, Published online: 11 March 2026; doi:10.1038/s41581-026-01061-5Here, the authors discuss explanations for missing disease-causing variants in Alport syndrome, how clinicians and laboratories might manage missing variants and how to care for patients when a clinical suspicion of Alport syndrome exists but no disease-causing variant has been identified.

Bridging structure and function: artificial intelligence-based modelling of kidney proteins

Nature Reviews Nephrology, Published online: 04 March 2026; doi:10.1038/s41581-026-01060-6Advances in artificial intelligence-driven algorithms and experimental technologies have revolutionized the field of protein modelling. This Review describes how these developments have provided unprecedented insights into the structure of key proteins within the kidney, improved understanding of the relationships between protein structure and stability, and enabled mechanistic interpretation of variants that underlie a variety of kidney pathologies.

The impact of social determinants of health on acute kidney injury

Nature Reviews Nephrology, Published online: 04 March 2026; doi:10.1038/s41581-026-01063-3Social determinants of health can have a considerable impact on patient outcomes. Here, the authors examine how social determinants of health contribute to the growing global burden of acute kidney injury and its inequities, and discuss key strategies for tackling disparities in acute kidney injury care and outcomes.

Replenishing methionine protects the host via kidney removal of excess cytokines from blood

Nature Reviews Nephrology, Published online: 02 March 2026; doi:10.1038/s41581-026-01064-2Replenishing methionine protects the host via kidney removal of excess cytokines from blood

Hepatokine regulation of kidney fibrosis

Susan J. Allison

Nature Reviews Nephrology, Published online: 02 March 2026; doi:10.1038/s41581-026-01065-1Hepatokine regulation of kidney fibrosis

When access outpaces ethics: reflections on dialysis expansion and health system integrity

Yot Teerawattananon

Nature Reviews Nephrology, Published online: 17 February 2026; doi:10.1038/s41581-026-01062-4Thailand’s dialysis policy reform, introduced in 2022, aimed to enable universal access to life-sustaining dialysis, but instead exposed systemic vulnerabilities that undermined dialysis quality, compromised patient safety and threatened sustainability of care. These outcomes highlight three ethical dilemmas — access versus quality, continuity of care, and financial conflicts of interest — and offer powerful insights into the ethical tensions that are shaping kidney care globally.

Graph neural networks for computational nephrology

Michael T. Schaub

Nature Reviews Nephrology, Published online: 16 February 2026; doi:10.1038/s41581-026-01059-zGraph neural networks offer a unifying artificial intelligence framework to model related objects, ranging from tissue architecture and geometrical relationships to patient similarity and multi-organ networks. Applications of this technology in nephrology include computational representation of kidney histopathology and modelling of the complex interactions between organs in kidney diseases.

Optimal patient care in advanced chronic kidney disease progressing to kidney failure

Christian Combe

Nature Reviews Nephrology, Published online: 10 February 2026; doi:10.1038/s41581-026-01056-2This Review discusses key strategies for managing patients with advanced chronic kidney disease progressing towards kidney failure. The authors examine drug and lifestyle interventions that can mitigate kidney and cardiovascular risks, and options for addressing kidney failure, including transplantation, dialysis and conservative kidney care, with an emphasis on informed shared decision-making.

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Neurologie

Deconstruction of a memory engram reveals distinct ensembles recruited at learning

Clément Pouget

Nature Neuroscience, Published online: 11 March 2026; doi:10.1038/s41593-026-02230-2Pouget et al. identified distinct CA1 neuron ensembles active during specific moments of fear learning and uncovered the core engram essential for memory formation.

Competitive interactions shape mammalian brain network dynamics and computation

Andrea I. Luppi

Nature Neuroscience, Published online: 11 March 2026; doi:10.1038/s41593-026-02205-3Brain network architecture may balance cooperation and competition across circuits. Here the authors use computational whole-brain modeling across three species to show that models with competition are more realistic, more personalized and perform better.

Author Correction: Autoimmune neuroinflammation leads to neuronal death via MIF nuclease-mediated parthanatos

Jackson W. Mace

Nature Neuroscience, Published online: 10 March 2026; doi:10.1038/s41593-026-02246-8Author Correction: Autoimmune neuroinflammation leads to neuronal death via MIF nuclease-mediated parthanatos

Persistent interferon signaling causes sensory neuron plasticity and pain before and during arthritis

Nature Neuroscience, Published online: 10 March 2026; doi:10.1038/s41593-026-02234-ySu et al. show that inflammatory arthritis pain stems from sustained interferon-driven MNK1/MNK2–elF4E signaling that sensitizes joint-innervating neurons. Blocking this pathway reverses pain, suggesting a targeted therapeutic strategy.

Neuronal tuning aligns dynamically with object and texture manifolds across the visual hierarchy

Nature Neuroscience, Published online: 10 March 2026; doi:10.1038/s41593-026-02207-1Visual neurons drive two AI models to compete in generating neuron-preferred features. The models form shared local motifs, while neuronal preference shifts from texture to object structure over time, revealing dynamic changes in visual coding.

How the brain can harm the heart

Nature Neuroscience, Published online: 09 March 2026; doi:10.1038/s41593-026-02243-xHow the brain can harm the heart

Liver-derived exercise factor boosts brain vasculature

Nature Neuroscience, Published online: 09 March 2026; doi:10.1038/s41593-026-02241-zLiver-derived exercise factor boosts brain vasculature

A year in the brain

William P. Olson

Nature Neuroscience, Published online: 09 March 2026; doi:10.1038/s41593-026-02244-wA year in the brain

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Tsunamis hiding in plain sight: spreading depression in clinical neurology

Nature Reviews Neurology, Published online: 11 March 2026; doi:10.1038/s41582-026-01191-1Spreading depression is a slowly propagating wave of mass depolarization that successively engulfs contiguous brain regions, causing transient neuronal hyperexcitability at its leading edge, followed by complete but reversible neuronal silence lasting minutes. Here, the authors present an evidence-based view of spreading depression as a probable cause of characteristic neurological signs and symptoms in numerous neurological conditions.

Modelling brain tumours with organoids: towards precision medicine in neuro-oncology

Marta de Lucas Sanz

Nature Reviews Neurology, Published online: 10 March 2026; doi:10.1038/s41582-026-01190-2Organoids provide a useful model to capture the heterogeneity of brain tumours. Here, the authors assess current methodologies for generating organoids from various types of brain tumour and discuss how these models have enhanced mechanistic insight into tumour initiation, progression and resistance to treatment, moving towards precision medicine.

We need to talk about risk in multiple sclerosis

Nature Reviews Neurology, Published online: 05 March 2026; doi:10.1038/s41582-026-01182-2Beth Grimsey lives with relapsing–remitting multiple sclerosis (MS) and is the Research Programme Manager at the MS Society in the UK. In this World View, she reflects on the uncertainty of MS, the ripple effects in families and the need for healthcare providers to communicate the knowns and unknowns.

Epidemiological principles behind worldwide growth of Parkinson disease — a bathtub analogy

Lisanne J. Dommershuijsen

Nature Reviews Neurology, Published online: 04 March 2026; doi:10.1038/s41582-026-01193-zParkinson disease (PD) is the fastest growing neurodegenerative condition worldwide, and proposed explanations for this growth include ageing, increased environmental exposures and better recognition. Using an adaptation of the classical epidemiological bathtub as a metaphor, we consider the potential contributions of epidemiological dynamics to the growth in PD and their implications for PD research.

Towards biomarker-based diagnosis of Parkinson disease

Nature Reviews Neurology, Published online: 13 February 2026; doi:10.1038/s41582-026-01185-zClinical diagnostic criteria for Parkinson disease (PD) have limitations, but no validated biomarker-based diagnostic framework currently exists. In this Review, Tolosa et al. examine progress towards biomarker-based diagnosis of PD, focusing on α-synuclein seed amplification assays alongside molecular, imaging and genetic markers.

Immune gateways bypass blood–brain barrier for drug delivery in stroke

Nature Reviews Neurology, Published online: 11 February 2026; doi:10.1038/s41582-026-01188-wThe natural migration pathway of CNS immune cells can be harnessed to deliver therapy to brain lesions in acute stroke, bypassing the blood–brain barrier (BBB), according to a new study published in Cell.

Recalled experiences of death: need for empirical research without prejudice

Nature Reviews Neurology, Published online: 11 February 2026; doi:10.1038/s41582-026-01186-yRecalled experiences of death: need for empirical research without prejudice

Reply to ‘Recalled experiences of death: need for empirical research without prejudice’

Nature Reviews Neurology, Published online: 11 February 2026; doi:10.1038/s41582-026-01187-xReply to ‘Recalled experiences of death: need for empirical research without prejudice’

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Rheumatologie

Bridging the gap: combining treat-to-target and difficult-to-treat strategies in the management of rheumatoid arthritis

Lilla Gunkl-Tóth

Nature Reviews Rheumatology, Published online: 02 March 2026; doi:10.1038/s41584-026-01354-wIn this Perspective, the authors discuss how integrating difficult-to-treat into the treat-to-target strategy could improve outcomes for those patients with rheumatoid arthritis who do not follow the standard treat-to-target trajectory. The proposed strategy is aimed at providing a more personalized approach to disease management for those patients with difficult-to-treat disease.

Neurodevelopmental comorbidities in juvenile systemic autoimmune and autoinflammatory diseases

Nature Reviews Rheumatology, Published online: 02 March 2026; doi:10.1038/s41584-026-01356-8Neurodevelopmental disorders frequently co-occur with juvenile systemic autoimmune and autoinflammatory diseases, driven by immune–neurodevelopmental interactions. Early screening, multidisciplinary care and personalized interventions are essential, alongside research into mechanisms, biomarkers and long-term outcomes to improve education, psychosocial wellbeing and quality of life.

Identifying fibromyalgia phenotypes based on psychological symptom burden

Ana Margarida Pinto

Nature Reviews Rheumatology, Published online: 26 February 2026; doi:10.1038/s41584-026-01362-wPsychological symptoms have a pivotal role in determining the severity of fibromyalgia. Findings now show that identifying and managing these symptoms during the early stages of disease could reveal disease phenotypes and improve the management of fibromyalgia.

What rheumatology can learn from oncology: a patient’s perspective

Nature Reviews Rheumatology, Published online: 25 February 2026; doi:10.1038/s41584-026-01364-8Drawing on my contrasting experiences as a patient in oncology and rheumatology, I have seen how the lack of precision-based diagnostics and meaningful endpoints limits progress in rheumatic disease. I believe biologically grounded classification systems and greater patient involvement are essential for more effective and responsive care.

Metabolic masqueraders of paediatric and adult rheumatic diseases

Nature Reviews Rheumatology, Published online: 25 February 2026; doi:10.1038/s41584-026-01352-yInborn errors of metabolism are a diverse group of disorders that can mimic rheumatological disease, often presenting with progressive joint and systemic involvement. This Review serves as a primer for rheumatologists, covering clinical aspects and potential mechanisms by which these metabolic alterations cause immune dysregulation.

Author Correction: Inflammation and pain as interconnected targets in axial spondyloarthritis

Xenofon Baraliakos

Nature Reviews Rheumatology, Published online: 16 February 2026; doi:10.1038/s41584-026-01363-9Author Correction: Inflammation and pain as interconnected targets in axial spondyloarthritis

Immune reset and immune retune: approaching cure?

Nature Reviews Rheumatology, Published online: 16 February 2026; doi:10.1038/s41584-026-01357-7The emergence of potent depletion therapies for the treatment of refractory autoimmunity has led to the concept of immune reset. Understanding whether immune reset equates to cure, and whether cure is achievable through non-depleting approaches, depends on the identification of immune biomarkers for measuring healthy and pathological immunity.

Vagus nerve stimulation shows clinical benefits for RA in pivotal trial

Nature Reviews Rheumatology, Published online: 10 February 2026; doi:10.1038/s41584-026-01359-5The findings of the pivotal RESET-RA trial demonstrate the clinical benefits and safety of an implanted neuromodulation device that stimulates the vagus nerve for the treatment of rheumatoid arthritis.

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Bridging the gap: combining treat-to-target and difficult-to-treat strategies in the management of rheumatoid arthritis

Lilla Gunkl-Tóth

Nature Reviews Rheumatology, Published online: 02 March 2026; doi:10.1038/s41584-026-01354-wIn this Perspective, the authors discuss how integrating difficult-to-treat into the treat-to-target strategy could improve outcomes for those patients with rheumatoid arthritis who do not follow the standard treat-to-target trajectory. The proposed strategy is aimed at providing a more personalized approach to disease management for those patients with difficult-to-treat disease.

Neurodevelopmental comorbidities in juvenile systemic autoimmune and autoinflammatory diseases

Nature Reviews Rheumatology, Published online: 02 March 2026; doi:10.1038/s41584-026-01356-8Neurodevelopmental disorders frequently co-occur with juvenile systemic autoimmune and autoinflammatory diseases, driven by immune–neurodevelopmental interactions. Early screening, multidisciplinary care and personalized interventions are essential, alongside research into mechanisms, biomarkers and long-term outcomes to improve education, psychosocial wellbeing and quality of life.

Identifying fibromyalgia phenotypes based on psychological symptom burden

Ana Margarida Pinto

Nature Reviews Rheumatology, Published online: 26 February 2026; doi:10.1038/s41584-026-01362-wPsychological symptoms have a pivotal role in determining the severity of fibromyalgia. Findings now show that identifying and managing these symptoms during the early stages of disease could reveal disease phenotypes and improve the management of fibromyalgia.

What rheumatology can learn from oncology: a patient’s perspective

Nature Reviews Rheumatology, Published online: 25 February 2026; doi:10.1038/s41584-026-01364-8Drawing on my contrasting experiences as a patient in oncology and rheumatology, I have seen how the lack of precision-based diagnostics and meaningful endpoints limits progress in rheumatic disease. I believe biologically grounded classification systems and greater patient involvement are essential for more effective and responsive care.

Metabolic masqueraders of paediatric and adult rheumatic diseases

Nature Reviews Rheumatology, Published online: 25 February 2026; doi:10.1038/s41584-026-01352-yInborn errors of metabolism are a diverse group of disorders that can mimic rheumatological disease, often presenting with progressive joint and systemic involvement. This Review serves as a primer for rheumatologists, covering clinical aspects and potential mechanisms by which these metabolic alterations cause immune dysregulation.

Author Correction: Inflammation and pain as interconnected targets in axial spondyloarthritis

Xenofon Baraliakos

Nature Reviews Rheumatology, Published online: 16 February 2026; doi:10.1038/s41584-026-01363-9Author Correction: Inflammation and pain as interconnected targets in axial spondyloarthritis

Immune reset and immune retune: approaching cure?

Nature Reviews Rheumatology, Published online: 16 February 2026; doi:10.1038/s41584-026-01357-7The emergence of potent depletion therapies for the treatment of refractory autoimmunity has led to the concept of immune reset. Understanding whether immune reset equates to cure, and whether cure is achievable through non-depleting approaches, depends on the identification of immune biomarkers for measuring healthy and pathological immunity.

Vagus nerve stimulation shows clinical benefits for RA in pivotal trial

Nature Reviews Rheumatology, Published online: 10 February 2026; doi:10.1038/s41584-026-01359-5The findings of the pivotal RESET-RA trial demonstrate the clinical benefits and safety of an implanted neuromodulation device that stimulates the vagus nerve for the treatment of rheumatoid arthritis.

Weitere Beiträge

Urologie

Prostate cancer screening: weighing the benefits and harms

Nature Reviews Urology, Published online: 06 March 2026; doi:10.1038/s41585-026-01133-yThe UK’s National Screening Committee recently recommended against population-level prostate cancer screening. Calls to override this guidance are intensifying, but acting without robust evidence might risk exposing thousands of men to unnecessary harm. Data-driven policy changes are crucial.

Revisiting the dual role of androgens and oestrogens in mammalian sex differentiation with a focus on genitalia

Emilie Elmelund

Nature Reviews Urology, Published online: 04 March 2026; doi:10.1038/s41585-026-01132-zThis Perspective presents historical and emerging evidence supporting a role of oestrogen signalling in male sexual differentiation, challenging the traditional androgen-centric view of reproductive development. Understanding the interplay between these two hormones is important to understanding development and also chemical risk, considering the susceptibility of these systems to disruption from exogenous substances.

Urinary tract infections in children

Nature Reviews Urology, Published online: 26 February 2026; doi:10.1038/s41585-026-01130-1In this Review, the authors describe and discuss the unique challenges of paediatric urinary tract infections including diagnosis, prevention and management, potential for adverse sequelae and key knowledge gaps.

Smooth muscle cell plasticity in pelvic organ prolapse

Nature Reviews Urology, Published online: 13 February 2026; doi:10.1038/s41585-026-01131-0Vaginal wall smooth muscle underpins pelvic support. In pelvic organ prolapse, smooth muscle cells are depleted and shift from a contractile phenotype to remodelling programmes, paralleling stress-induced switching in vascular disease. Defining trajectories and drivers could yield biomarkers and translatable, locally deliverable therapies to curb progression and recurrence.

ADT and activation of HGF and WNT axes in double-null prostate cancer

Dexter Hoi Long Leung

Nature Reviews Urology, Published online: 09 February 2026; doi:10.1038/s41585-026-01129-8In this Review, the authors discuss the causal role of current androgen deprivation therapy in prostate cancer progression, hormone refractoriness and double-null prostate cancer development. They highlight the underlying regulatory mechanisms by which androgen deprivation therapy elevates hepatocyte growth factor–hepatocyte growth factor receptor (HGF–MET) and WNT–β-catenin signalling, elevating exportin 1 (XPO1) and ribosomal protein activation to induce tumour aggressiveness, metastasis and double-null prostate cancer development.

Leveraging generative AI to enhance doctor–patient communication

Aalamnoor S. Pannu

Nature Reviews Urology, Published online: 05 February 2026; doi:10.1038/s41585-026-01127-wGenerative artificial intelligence (GAI) can produce high-quality lay summaries of medical literature, clinical trial information and guideline-based materials that meet recommended reading levels while preserving scientific integrity. Although important limitations remain, with appropriate safeguards, GAI has the potential to bridge longstanding gaps between certified medical knowledge and patient understanding.

Fathers matter too: sperm-borne epigenetic messages link paternal exposures to next-generation health

Sergio Pecorelli

Nature Reviews Urology, Published online: 04 February 2026; doi:10.1038/s41585-026-01128-9Historically, the contribution of fathers to offspring health has been neglected, with the focus on mothers. However, growing evidence shows the important influence that the environmental factors the fathers experience has on sperm epigenetics and, consequently, the health of the next generation.

Management of surgical menopause in female patients with bladder cancer undergoing radical cystectomy

Nature Reviews Urology, Published online: 30 January 2026; doi:10.1038/s41585-026-01124-zSurgical menopause occurs in premenopausal women who undergo radical cystectomy with bilateral oophorectomy to treat bladder cancer. This Review discusses the pathophysiology of surgical menopause in these patients and highlights current strategies to mitigate associated symptoms and long-term health risks.

Weitere Beiträge

Prostate cancer screening: weighing the benefits and harms

Nature Reviews Urology, Published online: 06 March 2026; doi:10.1038/s41585-026-01133-yThe UK’s National Screening Committee recently recommended against population-level prostate cancer screening. Calls to override this guidance are intensifying, but acting without robust evidence might risk exposing thousands of men to unnecessary harm. Data-driven policy changes are crucial.

Revisiting the dual role of androgens and oestrogens in mammalian sex differentiation with a focus on genitalia

Emilie Elmelund

Nature Reviews Urology, Published online: 04 March 2026; doi:10.1038/s41585-026-01132-zThis Perspective presents historical and emerging evidence supporting a role of oestrogen signalling in male sexual differentiation, challenging the traditional androgen-centric view of reproductive development. Understanding the interplay between these two hormones is important to understanding development and also chemical risk, considering the susceptibility of these systems to disruption from exogenous substances.

Urinary tract infections in children

Nature Reviews Urology, Published online: 26 February 2026; doi:10.1038/s41585-026-01130-1In this Review, the authors describe and discuss the unique challenges of paediatric urinary tract infections including diagnosis, prevention and management, potential for adverse sequelae and key knowledge gaps.

Smooth muscle cell plasticity in pelvic organ prolapse

Nature Reviews Urology, Published online: 13 February 2026; doi:10.1038/s41585-026-01131-0Vaginal wall smooth muscle underpins pelvic support. In pelvic organ prolapse, smooth muscle cells are depleted and shift from a contractile phenotype to remodelling programmes, paralleling stress-induced switching in vascular disease. Defining trajectories and drivers could yield biomarkers and translatable, locally deliverable therapies to curb progression and recurrence.

ADT and activation of HGF and WNT axes in double-null prostate cancer

Dexter Hoi Long Leung

Nature Reviews Urology, Published online: 09 February 2026; doi:10.1038/s41585-026-01129-8In this Review, the authors discuss the causal role of current androgen deprivation therapy in prostate cancer progression, hormone refractoriness and double-null prostate cancer development. They highlight the underlying regulatory mechanisms by which androgen deprivation therapy elevates hepatocyte growth factor–hepatocyte growth factor receptor (HGF–MET) and WNT–β-catenin signalling, elevating exportin 1 (XPO1) and ribosomal protein activation to induce tumour aggressiveness, metastasis and double-null prostate cancer development.

Leveraging generative AI to enhance doctor–patient communication

Aalamnoor S. Pannu

Nature Reviews Urology, Published online: 05 February 2026; doi:10.1038/s41585-026-01127-wGenerative artificial intelligence (GAI) can produce high-quality lay summaries of medical literature, clinical trial information and guideline-based materials that meet recommended reading levels while preserving scientific integrity. Although important limitations remain, with appropriate safeguards, GAI has the potential to bridge longstanding gaps between certified medical knowledge and patient understanding.

Fathers matter too: sperm-borne epigenetic messages link paternal exposures to next-generation health

Sergio Pecorelli

Nature Reviews Urology, Published online: 04 February 2026; doi:10.1038/s41585-026-01128-9Historically, the contribution of fathers to offspring health has been neglected, with the focus on mothers. However, growing evidence shows the important influence that the environmental factors the fathers experience has on sperm epigenetics and, consequently, the health of the next generation.

Management of surgical menopause in female patients with bladder cancer undergoing radical cystectomy

Nature Reviews Urology, Published online: 30 January 2026; doi:10.1038/s41585-026-01124-zSurgical menopause occurs in premenopausal women who undergo radical cystectomy with bilateral oophorectomy to treat bladder cancer. This Review discusses the pathophysiology of surgical menopause in these patients and highlights current strategies to mitigate associated symptoms and long-term health risks.

Weitere Beiträge

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