Nature Reviews Cardiology, Published online: 26 January 2026; doi:10.1038/s41569-026-01247-1The environmental exposome, which includes pollution, contamination, climate and social determinants of health, is intricately involved in the pathophysiology of heart failure. In this Review, Hahad and colleagues explore the complex relationship between environmental stressors and heart failure, advocating for their inclusion alongside traditional risk factors and highlighting the need for new strategies to address the effects of the exposome on public health.

Nature Reviews Cardiology, Published online: 22 January 2026; doi:10.1038/s41569-026-01256-0Treatment with low-dose IL-2 increases regulatory T cell numbers and reduces arterial inflammation in patients with an acute coronary syndrome and residual systemic inflammation compared with placebo, according to findings from the IVORY trial.

Nature Reviews Cardiology, Published online: 19 January 2026; doi:10.1038/s41569-026-01252-4The use of β-blockers after myocardial infarction: no doubts remain

Nature Reviews Cardiology, Published online: 14 January 2026; doi:10.1038/s41569-026-01250-6In this Review, Kaiser and Nicolai summarize our understanding of procoagulant platelets, describing the signalling pathways that control platelet procoagulant activation and discussing the role of procoagulant platelets in venous and arterial thrombosis, as well as potential therapeutic approaches to target these platelets in thrombotic and thromboinflammatory disorders, including cardiovascular disease, septic inflammation and immune complex-mediated diseases.

Nature Reviews Clinical Oncology, Published online: 23 January 2026; doi:10.1038/s41571-025-01115-wThis Review outlines the fundamental role of chimeric antigen receptor (CAR) T cell therapy for children, adolescents and young adults (CAYAs) with relapsed and/or refractory B cell acute lymphoblastic leukaemia, emphasizing the crucial need to further exploit CAR T cells and other immunotherapies to improve survival with broadened access across disease states. Opportunities and challenges for expanding CAR T cell therapy to other haematological and non-haematological malignancies in CAYAs are also discussed.

Nature Reviews Clinical Oncology, Published online: 19 January 2026; doi:10.1038/s41571-026-01121-6Author Correction: Advances in the management of localized bladder cancers

Nature Reviews Clinical Oncology, Published online: 06 January 2026; doi:10.1038/s41571-025-01109-8Treatment selection based on the presence of one or more specific biomarkers has the potential to optimize treatment outcomes; nonetheless, most patients lack a specific biomarker that is predictive of benefit from one or more targeted treatment approaches. In this Review, the authors describe the potential of computational analysis approaches to enable the discovery of more complex predictive biomarkers based on comprehensive analysis of large clinical and preclinical datasets and thus address this unmet need.

Nature Reviews Neurology, Published online: 16 January 2026; doi:10.1038/s41582-025-01173-9Translation of evidence about dementia risk into effective public health policy is a challenge. In this Consensus Statement, Demnitz-King and colleagues present 56 policy recommendations for dementia prevention, providing policymakers with a foundation for designing and implementing evidence-based dementia prevention strategies, prioritizing clear communication, targeted intervention and sustained research investment.

Nature Reviews Neurology, Published online: 02 January 2026; doi:10.1038/s41582-025-01177-5Emerging genomic studies across Africa are revealing how decades of population bias have constrained understanding of disease mechanisms. New evidence in Parkinson disease genetics illustrates how overlooking Africa’s vast genetic diversity not only limits scientific insight but also slows the development of medical and biotechnological innovations that are vital for advancing global health.

Nature Reviews Neurology, Published online: 10 December 2025; doi:10.1038/s41582-025-01178-4Loss of TDP43 from the nucleus in amyotrophic lateral sclerosis and frontemporal dementia leads to changes in polyadenylation that alter mRNA processing, according to new research.

Nature Reviews Neurology, Published online: 08 December 2025; doi:10.1038/s41582-025-01174-8A new study indicates that physical activity reduces cognitive decline, possibly through attenuation of tau accumulation in the brain.