Nature Reviews Cardiology, Published online: 21 July 2025; doi:10.1038/s41569-025-01187-2In this Expert Recommendation, Lauder and colleagues compare the latest European Society of Cardiology and European Society of Hypertension guidelines on hypertension, highlight the key consensus recommendations and compare differing approaches to definitions, classification, diagnosis and treatment, with the aim to help health-care professionals in their decision-making to improve the management of hypertension.

Nature Reviews Cardiology, Published online: 18 July 2025; doi:10.1038/s41569-025-01186-3In this Perspective article, Saba and Libby review the latest evidence highlighting the lack of a correlation between stenosis severity and the risk of atherosclerosis-induced thrombotic complications and question the overreliance on stenosis grading for therapeutic decision-making.

Nature Reviews Cardiology, Published online: 16 July 2025; doi:10.1038/s41569-025-01184-5In this Review, Narayan and colleagues discuss global disparities in access to digital health technologies, with a focus on cardiovascular medicine. The authors summarize the factors that affect access at various levels of society and present solutions that target each of these levels, culminating in a personalized framework to improve access to digital health technologies.

Nature Reviews Cardiology, Published online: 27 June 2025; doi:10.1038/s41569-025-01183-6Treatment of cardiomyopathies has historically focused on symptom management. In this Review, Elliott and colleagues discuss how elucidation of the complex cellular and molecular pathways has led to the development of novel therapeutic agents that modify or mitigate the effects of causative genetic variants, enabling tailored treatment for cardiomyopathies.

Nature Reviews Clinical Oncology, Published online: 22 July 2025; doi:10.1038/s41571-025-01058-2Despite several decades of research that has revealed roles in the development and progression of many solid tumours, clinical translation of research targeting epithelial–mesenchymal transition (EMT) has thus far been limited. In this Review, the authors provide a summary of the role of EMT in cancer development and progression in the context of this lack of clinical translation, summarize the current status of direct or indirect EMT-modulating agents in clinical development, and highlight the major barriers to the development of EMT-related clinical interventions.

Nature Reviews Clinical Oncology, Published online: 14 July 2025; doi:10.1038/s41571-025-01052-8Radiotherapy has an established role in the treatment of many patients with cancer, with evidence suggesting that this modality can also have immunostimulatory effects in certain scenarios. More recently, evidence has emerged supporting a role of the microbiome in influencing the incidence and severity of toxicities in patients receiving radiotherapy as well as in mediating possible synergy with other therapeutic interventions, including immunotherapy. In this Review, the authors explore the clinical potential of these emerging relationships.

Nature Reviews Clinical Oncology, Published online: 07 July 2025; doi:10.1038/s41571-025-01041-xIn these Evidence-Based Guidelines, a multidisciplinary panel of experts from the European Hematology Association and the European Myeloma Network provide key treatment recommendations for patients with smouldering multiple myeloma, and newly diagnosed or relapsed and/or refractory multiple myeloma, addressing the use of established drugs and novel immunotherapies as well as the management of disease-specific and treatment-related complications and adverse events.

Nature Reviews Clinical Oncology, Published online: 01 July 2025; doi:10.1038/s41571-025-01056-4A new first-line option for advanced-stage anal squamous cell carcinoma

Nature Reviews Endocrinology, Published online: 14 July 2025; doi:10.1038/s41574-025-01151-7Obesity-related subfertility is an increasingly recognized concern. Pharmacotherapies (particularly glucagon-like peptide 1 receptor agonists and combination therapies), alongside lifestyle intervention, enable meaningful and sustainable weight loss in people with and without type 2 diabetes mellitus. Weight loss can benefit sperm parameters, but the optimal amount and rate of weight loss requires further study.

Nature Reviews Endocrinology, Published online: 14 July 2025; doi:10.1038/s41574-025-01143-7Consumption of ultra-processed foods (UPF) is increasingly linked to the development of obesity, on both an individual and a global scale. This Review assesses the role of UPF in obesity, examining the epidemiological evidence, biological mechanisms and implications for policymakers.

Nature Reviews Endocrinology, Published online: 07 July 2025; doi:10.1038/s41574-025-01150-8mRNA-based enzyme replacement for propionic acidaemia

Nature Reviews Gastroenterology & Hepatology, Published online: 21 July 2025; doi:10.1038/s41575-025-01087-3In the USA, colorectal cancer (CRC) is a leading cause of death and a public health challenge due to persisting disparities between Black and White individuals. This Review examines Black–White disparities in CRC outcomes, bringing health-care and systemic inequities into focus.

Nature Reviews Gastroenterology & Hepatology, Published online: 07 July 2025; doi:10.1038/s41575-025-01089-1In this Review, Yu and colleagues describe the role of the gut microbiome and the gut–liver axis in metabolic dysfunction-associated steatotic liver disease (MASLD) and MASLD-related hepatocellular carcinoma (HCC). They discuss clinical implications for the diagnosis and treatment of MASLD and MASLD-related HCC.

Nature Reviews Gastroenterology & Hepatology, Published online: 27 June 2025; doi:10.1038/s41575-025-01095-3Reply to ‘Pregnancy and liver health: delivering new collaborations to advance the MASLD and MASH field’

Nature Reviews Gastroenterology & Hepatology, Published online: 27 June 2025; doi:10.1038/s41575-025-01094-4Pregnancy and liver health: delivering new collaborations to advance the MASLD and MASH field

Nature Reviews Rheumatology, Published online: 10 July 2025; doi:10.1038/s41584-025-01281-2Familial Mediterranean fever (FMF) is a monogenic autoinflammatory disorder with high prevalence in Mediterranean populations. Considerable advances in the management of FMF have been made in the past decade, with respect to the use of biologic drugs and understanding colchicine resistance. The 2024 updated FMF management recommendations are timely and reflect these advances.

Nature Reviews Rheumatology, Published online: 08 July 2025; doi:10.1038/s41584-025-01283-0A study provides insights into the factors that regulate synovial fibroblast interactions with endothelial cells in RA and subsequent pathogenic neovascularization.

Nature Reviews Rheumatology, Published online: 08 July 2025; doi:10.1038/s41584-025-01285-yThe anti-fibrotic and anti-inflammatory agent nerandomilast has shown promise for the treatment of both idiopathic and progressive pulmonary fibrosis in phase III trials.

Nature Reviews Rheumatology, Published online: 07 July 2025; doi:10.1038/s41584-025-01276-zThis Review provides an overview of how platelets promote immunothrombosis in rheumatic disease. The authors discuss the different ways in which platelets and immunothrombosis can be targeted for therapeutic intervention.