Nature Reviews Cardiology, Published online: 16 June 2026; doi:10.1038/s41569-026-01304-9In this Review, Nerlekar and colleagues describe how the collective biology of adipose depots, rather than quantity alone, drives cardiometabolic risk, highlight how patterns of fat distribution specific to sex and ethnicity can modulate this risk, and summarize numerous pharmacological interventions to target adipose tissue for the reduction of cardiometabolic risk.

Nature Reviews Cardiology, Published online: 09 June 2026; doi:10.1038/s41569-026-01315-6In patients with advanced, symptomatic heart failure with reduced ejection fraction refractory to guideline-directed therapy, transplantation of a tissue allograft produced from induced pluripotent stem cells promotes heart remuscularization and leads to increases in heart wall thickness, left ventricular ejection fraction and quality of life at 3 months, according to an interim analysis of the ongoing, phase I–II BioVAT-HF clinical trial.

Nature Reviews Cardiology, Published online: 28 May 2026; doi:10.1038/s41569-026-01309-4Hypertensive disorders experienced during pregnancy can continue to increase cardiovascular risk after childbirth. However, adequate follow-up (including blood pressure management, risk stratification and cardiometabolic prevention) is not always incorporated into postpartum care. A life-course pathway that integrates surveillance and targeted interventions could reduce inequities and improve long-term cardiovascular outcomes.

Nature Reviews Cardiology, Published online: 21 May 2026; doi:10.1038/s41569-026-01307-6The beating of the heart does more than circulate blood; its rhythmic contractions generate forces to create a biomechanical environment that suppresses tumour growth. This finding, from a new study by Ciucci and colleagues, highlights an underappreciated role for cardiac mechanics in cancer biology.

Nature Reviews Clinical Oncology, Published online: 15 June 2026; doi:10.1038/s41571-026-01178-3Teclistamab monotherapy improves survival in RRMM

Nature Reviews Clinical Oncology, Published online: 12 June 2026; doi:10.1038/s41571-026-01176-5Daraxonrasib effective in metastatic pancreatic ductal adenocarcinoma

Nature Reviews Clinical Oncology, Published online: 10 June 2026; doi:10.1038/s41571-026-01160-zDespite considerable improvements in the outcomes in patients with hepatocellular carcinoma (HCC), many outstanding research questions remain unanswered. Furthermore, significant findings from successful phase III trials have not always been translated into guideline-recommended therapies, implying a need for improved standardization of trial end points. In this Consensus Statement, representatives of four major societies (the European Association for the Study of the Liver (EASL), the American Association for the Study of Liver Diseases (AASLD), the International Liver Cancer Association (ILCA) and the American Society of Clinical Oncology (ASCO)) convened to provide guidance on end point selection for clinical trials conducted in various settings including surveillance, and early-stage, intermediate-stage and advanced-stage HCC.

Nature Reviews Endocrinology, Published online: 12 June 2026; doi:10.1038/s41574-026-01265-6This Review highlights adipose humoral and neuronal pathways that operate through inter-organ communication to regulate systemic metabolism, examines how physiological and pathological contexts shape these signals, and explores emerging technologies and translational opportunities for targeting adipose networks in metabolic disease.

Nature Reviews Endocrinology, Published online: 03 June 2026; doi:10.1038/s41574-026-01269-2Intestinal mitochondrial complex I inhibition essential for clinical benefits of metformin

Nature Reviews Endocrinology, Published online: 02 June 2026; doi:10.1038/s41574-026-01267-4Elucidating the structure of TRH: a defining moment for modern neuroendocrinology

Nature Reviews Gastroenterology & Hepatology, Published online: 15 June 2026; doi:10.1038/s41575-026-01219-3Steatotic liver disease (SLD) burden is rising worldwide, and Latin America is disproportionately affected. This Review provides a detailed summary of SLD epidemiology in the region, identifies gaps in clinical management and research, and provides suggestions to improve health outcomes.

Nature Reviews Gastroenterology & Hepatology, Published online: 11 June 2026; doi:10.1038/s41575-026-01220-wDietary perturbation and microbial adaptation in the gut

Nature Reviews Gastroenterology & Hepatology, Published online: 04 June 2026; doi:10.1038/s41575-026-01218-4A people-first, systems-oriented approach to liver disease in HIV infection

Nature Reviews Neurology, Published online: 15 June 2026; doi:10.1038/s41582-026-01235-6A key protein in the initiation of autophagy and mitophagy is reduced in Alzheimer disease and could be a novel therapeutic target, new research has shown.

Nature Reviews Neurology, Published online: 10 June 2026; doi:10.1038/s41582-026-01233-8The apolipoprotein E ε4 allele is associated with relapse-associated disability worsening in people with multiple sclerosis, new research reveals.

Nature Reviews Neurology, Published online: 10 June 2026; doi:10.1038/s41582-026-01234-7The transcription factor ZFP384 reduces the reparative capacity of microglia after stroke and could be targeted therapeutically to improve stroke outcomes, according to recent preclinical research.

Nature Reviews Neurology, Published online: 03 June 2026; doi:10.1038/s41582-026-01218-7Sensitive outcome measures are urgently needed for trials of disease-modifying therapies for degenerative ataxias. In this Consensus Statement, the Ataxia Global Initiative MRI Biomarkers Working Group provides evidence-based, disease-specific recommendations for the selection of MRI end-points for trials, and recommends further research to address knowledge gaps.

Nature Reviews Rheumatology, Published online: 15 June 2026; doi:10.1038/s41584-026-01391-5This Review examines emerging laboratory, imaging and multi-omics biomarkers in rheumatoid arthritis, highlighting roles in diagnosis, prognosis, treatment selection and comorbidity management, and emphasizing challenges and opportunities for translating biomarker advances into routine clinical practice and improved patient outcomes.

Nature Reviews Rheumatology, Published online: 08 June 2026; doi:10.1038/s41584-026-01390-620 years ago, the modern classification of inflammation against self was developed, wherein an immunological disease continuum was invoked, as autoimmunity alone inadequately explained the spectrum of self-directed inflammation.

Nature Reviews Rheumatology, Published online: 29 May 2026; doi:10.1038/s41584-026-01386-2This Review examines evolving comorbidity patterns in rheumatoid arthritis, highlighting improving trends in some conditions, persistent burdens in others, and implications for treatment selection, preventive screening and integrated, individualized care.

Nature Reviews Rheumatology, Published online: 27 May 2026; doi:10.1038/s41584-026-01389-zSymptomatic knee osteoarthritis at an early structural stage could provide a window of opportunity for intervention. Symptomatic knees without definite radiographic osteoarthritis can already show structural joint changes detectable on MRI; however, the greater sensitivity of MRI must be balanced against the risks of overdiagnosis and overtreatment.

Nature Reviews Urology, Published online: 08 June 2026; doi:10.1038/s41585-026-01162-7Mature sperm acquire mRNAs from epididymal extracellular vesicles during post-testicular maturation. These findings challenge the idea that sperm mRNAs are merely residual transcripts and suggest an underappreciated mechanism of paternal epigenetic inheritance.

Nature Reviews Urology, Published online: 05 June 2026; doi:10.1038/s41585-026-01157-4In this Perspective, the authors examine how germline variation, somatic alterations and environmentally induced reprogramming converge on the epigenome to shape African prostate tumour biology. They outline emerging mechanistic insights, highlight methodological challenges and propose future directions.

Nature Reviews Urology, Published online: 04 June 2026; doi:10.1038/s41585-026-01143-wThis Review discusses evidence of the utility of MRI before biopsy in the prostate cancer diagnostic pathway, particularly considering biopsy-naive patients, patients with previous negative biopsies and patients on active surveillance. Future perspectives of combining MRI with biomarkers and/or other novel biopsy modalities to improve the detection of clinically significant cancers are also explored.