Nature Reviews Cardiology, Published online: 28 July 2026; doi:10.1038/s41569-026-01330-7Targeting systemic metabolism through mild mitochondrial uncoupling with a controlled-release mitochondrial protonophore can reduce atherosclerosis in a mouse model of cardiometabolic syndrome, even when administered at late stages of disease progression.

Nature Reviews Cardiology, Published online: 23 July 2026; doi:10.1038/s41569-026-01322-7In this Review, Wang and Dobreva discuss nuclear and chromatin organization and remodelling during cardiac development, disease and ageing, highlight emerging methods to investigate nuclear architecture, describe how mechanical and metabolic signals shape the cardiac 4D nucleome, and examine the therapeutic and translational implications for cardiovascular health and disease.

Nature Reviews Cardiology, Published online: 13 July 2026; doi:10.1038/s41569-026-01312-9In this Roadmap from the World Heart Federation, cardiac rehabilitation is reframed as programmes to promote lifelong cardiovascular health. Redfern et al. identify roadblocks and propose multifaceted solutions, together with international case studies of successful implementation.

Nature Reviews Clinical Oncology, Published online: 31 July 2026; doi:10.1038/s41571-026-01191-6In MonumenTAL-3, the G-protein-coupled receptor class C group 5 memberD-directed bispecific T cell engager talquetamab combined with either daratumumab or daratumumab–pomalidomide conferred significantly longer progression-free survival than daratumumab–pomalidomide–dexamethasone in patients with relapsed and/or refractory multiple myeloma (≥1 prior line of therapy). These results herald a new therapeutic option for such patients but also raise questions regarding how talquetamab-based regimens should be integrated with B cell maturation antigen-directed T cell-redirecting therapies.

Nature Reviews Clinical Oncology, Published online: 29 July 2026; doi:10.1038/s41571-026-01186-3Current treatment approaches for patients with multiple myeloma are characterized by a ‘more is better’ philosophy aiming for deep and long-term clinical responses. The authors of this Review challenge this paradigm, presenting several de-escalation strategies that do not compromise long-term efficacy and proposing a framework for the design of trials testing further de-escalation approaches.

Nature Reviews Clinical Oncology, Published online: 24 July 2026; doi:10.1038/s41571-026-01181-8Advances in multimodal analyses of diverse cell types and cellular products present in the blood have presented opportunities to non-invasively and repeatedly assess systemic immune dynamics, predict and monitor responses to immunotherapies, and detect emerging resistance in patients with cancer. In this Review, the authors discuss various insights on systemic antitumour immune responses that can be gleaned through such liquid biopsy-based analysis of circulating tumour-derived biomarkers and/or immune cells and their implications for immunotherapy.

Nature Reviews Clinical Oncology, Published online: 16 July 2026; doi:10.1038/s41571-026-01187-2Second-line 177Lu-edotreotide shows promise in GEP NETs

Nature Reviews Endocrinology, Published online: 30 July 2026; doi:10.1038/s41574-026-01277-2Understanding the key mechanisms underlying sleep and wake states is essential for developing effective treatments for sleep disorders. Here, the authors discuss how the orexin (also known as hypocretin) system — a central regulator of sleep and wakefulness — is a key target in the development of treatments for sleep disorders.

Nature Reviews Endocrinology, Published online: 28 July 2026; doi:10.1038/s41574-026-01290-5Local catecholamine catabolism blunts lipolysis in ageing adipose tissue

Nature Reviews Endocrinology, Published online: 21 July 2026; doi:10.1038/s41574-026-01279-0Obesity is a chronic, adiposity-based disease with multiple, competing definitions. In the past 2 years, major professional societies have advanced new diagnostic frameworks that incorporate multimodal assessment of adiposity and its clinical consequences. In this Review, Tandar et al. evaluate contemporary anthropometric and body composition measurements, synthesize new frameworks and guidelines for the diagnosis and staging of obesity, and discuss their implications for clinical practice.

Nature Reviews Gastroenterology & Hepatology, Published online: 31 July 2026; doi:10.1038/s41575-026-01232-6Anorectal bacterial sexually transmitted infections (STIs) remain a global health challenge. This Review provides an overview of anorectal bacterial STIs focusing on chlamydia, gonorrhoea and syphilis, with insights into global burden, pathophysiology, management and prevention, as well as highlighting knowledge gaps and research priorities.

Nature Reviews Gastroenterology & Hepatology, Published online: 20 July 2026; doi:10.1038/s41575-026-01234-4Two independent Delphi-driven consensus initiatives have established the first standardized frameworks for defining, measuring and managing intrapancreatic fat. Their areas of agreement provide a foundation for clinical recognition, while key divergences in terminology, thresholds and evidence appraisal highlight critical questions that must be resolved through rigorous collaborative research.

Nature Reviews Gastroenterology & Hepatology, Published online: 17 July 2026; doi:10.1038/s41575-026-01238-0Precision adherence support for hepatitis C treatment

Nature Reviews Gastroenterology & Hepatology, Published online: 16 July 2026; doi:10.1038/s41575-026-01236-2Steatosis fuels replacement liver metastases in colorectal cancer

Nature Reviews Nephrology, Published online: 30 July 2026; doi:10.1038/s41581-026-01112-xTaiwan carries one of the world’s heaviest kidney disease burdens globally; however, its single-payer universal health-care system has enabled policy-driven transformation of kidney care through population-level screening, multidisciplinary pay-for-performance programmes, data-driven surveillance and digital innovation. These strategies have reduced disease incidence and improved outcomes, and provide a replicable model for health systems elsewhere.

Nature Reviews Nephrology, Published online: 28 July 2026; doi:10.1038/s41581-026-01107-8The complexity of the host responses that underlie sepsis-associated acute kidney injury (SA-AKI) complicates patient management and contributes to its high mortality. Here, the authors examine insights into the pathophysiology of SA-AKI gained from the integration of high-resolution spatial transcriptomics with other multi-omics approaches, and consider how these technologies might enable targeted therapeutic interventions.

Nature Reviews Nephrology, Published online: 27 July 2026; doi:10.1038/s41581-026-01113-wWNT organizers control nephron patterning in organoids

Nature Reviews Nephrology, Published online: 24 July 2026; doi:10.1038/s41581-026-01110-zThe prevalence of kidney disease is increasing in children and young adults, who face a lifetime of chronic disease with considerable morbidity and mortality. However, a critical shortage in the paediatric nephrology workforce and deficiencies in paediatric-to-adult transition care mean that we fail to meet the needs of this vulnerable population. Paediatric and adult nephrologists need to take collaborative action to address this crisis.

Nature Reviews Rheumatology, Published online: 31 July 2026; doi:10.1038/s41584-026-01418-xAn osteoimmunomodulatory implant that enables finely tuned release of magnesium ions could offer a way to enhance osteoporotic bone repair.

Nature Reviews Rheumatology, Published online: 30 July 2026; doi:10.1038/s41584-026-01417-yPD-L2-mediated activation of PD-1 signalling in rheumatoid arthritis suppresses pro-inflammatory cytokine production and regulates pathogenic B cell responses.

Nature Reviews Rheumatology, Published online: 22 July 2026; doi:10.1038/s41584-026-01397-zIn rheumatoid arthritis (RA) a hypoxic gradient develops in the synovium, which shapes inflammation and immune responses. In this Review, the authors provide insights into the role of hypoxia in the pathogenesis of RA, discuss its role in the wider integrated signalling network that drives inflammation and highlight how hypoxia can be targeted therapeutically to treat RA.

Nature Reviews Rheumatology, Published online: 13 July 2026; doi:10.1038/s41584-026-01408-zLymph node architecture sequesters B cells away from effector cells, limiting antibody-mediated depletion and highlighting tissue remodelling as a strategy to improve therapeutic responses.

Nature Reviews Urology, Published online: 27 July 2026; doi:10.1038/s41585-026-01174-3This Review synthesizes current evidence on the urinary microbiome in overactive bladder and bladder pain syndrome/interstitial cystitis, focusing on translational relevance. The authors discussed mechanistic links to symptoms and emerging interventions. Integration into clinical practice is also discussed, highlighting crucial gaps in causality, biomarkers and therapeutic targeting.

Nature Reviews Urology, Published online: 20 July 2026; doi:10.1038/s41585-026-01175-2Extending a pleasure-based paradigm: reflections on male-centred assumptions in sexual medicine

Nature Reviews Urology, Published online: 09 July 2026; doi:10.1038/s41585-026-01172-5This Review provides an overview of currently available intraprostatic immunotherapy approaches, discussing rationale, main strategies, results from early-phase trials and the current limitations associated with this approach. The authors also discuss future perspectives regarding clinical implementation, describing opportunities and challenges.

Nature Reviews Urology, Published online: 26 June 2026; doi:10.1038/s41585-026-01173-4Cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction, which has long been associated with systemic disease, also has under-recognized roles in male fertility. This Review outlines its contributions to spermatogenesis, sperm function and ion homeostasis, and links reduced expression to impaired sperm quality, highlighting emerging therapeutic strategies that might improve reproductive outcomes in individuals with CFTR deficiency.